Mental and behavioural disorders due to alcohol

F5_ALCOHOL

psychosis: An abnormal condition of the mind that involves a loss of contact with reality. People experiencing psychosis may exhibit personality changes and thought disorder. Depending on its severity, this may be accompanied by unusual or bizarre behavior, as well as difficulty with social interaction and impairment in carrying out daily life activities.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F10

Hospital discharge: ICD-9 303|291

Hospital discharge: ICD-8 291

Hospital discharge: excluded ICD-10 F10.0

Cause of death: ICD-10 F10

Cause of death: ICD-9 303|291

Cause of death: ICD-8 291

Cause of death: excluded ICD-10 F10.1

14560

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

13598

Check minimum number of events None

13598

Include endpoints

F5_ALCOHOLAC

F5_ALCOHOL_DEPENDENCE

16558

F5_ALCOHOL

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF5

Parent code in ICD-10 F10-F19

Name in latin Perturbationes mentis et modi se gerendi ex usu alcohol

Similar endpoints

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List of similar endpoints to Mental and behavioural disorders due to alcohol based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

16077

5168

10909

Unadjusted prevalence (%)

5.21

2.98

8.08

Mean age at first event (years)

44.80

40.59

46.80

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Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	5.26 [4.42, 6.26]	3.2e-78	2895
15 years	0.01	3.08 [2.65, 3.57]	1.4e-49	1156
5 years	0.00	5.29 [4.65, 6.03]	<1e-100	634
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_ALCOHOL – Mental and behavioural disorders due to alcohol
GWS hits: 4

Survival analyses between endpoints

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Plot

before Mental and behavioural disorders due to alcohol
after Mental and behavioural disorders due to alcohol

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Table

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Drugs most likely to be purchased after Mental and behavioural disorders due to alcohol

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