Functional dyspepsia

K11_FUNCDYSP

dyspepsia: An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K30

Hospital discharge: ICD-9 5368A

Hospital discharge: ICD-8 5361

Cause of death: ICD-10 K30

Cause of death: ICD-9 5368A

Cause of death: ICD-8 5361

6915

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6910

Check minimum number of events None

6910

Include endpoints None

6910

K11_FUNCDYSP

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K20-K31

Name in latin Dyspepsia

Similar endpoints

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List of similar endpoints to Functional dyspepsia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	6666	4588	2078
Unadjusted prevalence (%)	2.16	2.64	1.54
Mean age at first event (years)	53.46	51.99	56.72

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.02 [1.51, 2.69]	1.7e-6	407
15 years	0.01	1.22 [0.94, 1.58]	1.4e-1	188
5 years	0.00	2.50 [1.94, 3.23]	1.7e-12	127
1 year	0.00	4.58 [3.26, 6.44]	2.3e-18	47

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_FUNCDYSP – Functional dyspepsia
GWS hits: 0

Survival analyses between endpoints

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Plot

before Functional dyspepsia
after Functional dyspepsia

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Table

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Drugs most likely to be purchased after Functional dyspepsia

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