Barret oesophagus

K11_BARRET

Barrett's esophagus: Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K22.7

Hospital discharge: ICD-9 5301B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K22.7

Cause of death: ICD-9 5301B

Cause of death: ICD-8 $!$

810

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

810

Check minimum number of events None

810

Include endpoints None

810

K11_BARRET

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K22

Similar endpoints

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List of similar endpoints to Barret oesophagus based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	793	277	516
Unadjusted prevalence (%)	0.26	0.16	0.38
Mean age at first event (years)	64.40	64.44	64.38

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.16 [1.55, 6.45]	1.6e-3	38
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_BARRET – Barret oesophagus
GWS hits: 0

Survival analyses between endpoints

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Plot

before Barret oesophagus
after Barret oesophagus

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Table

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Drugs most likely to be purchased after Barret oesophagus

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