Hypersensitivity pneumonitis due to organic dust

J10_HYPERSPNEUMONI

extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J67

Hospital discharge: ICD-9 495

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 J67

Cause of death: ICD-9 495

Cause of death: ICD-8 $!$

374

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

363

Check minimum number of events None

363

Include endpoints None

363

J10_HYPERSPNEUMONI

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 J60-J70

Name in latin Pneumonitis/alveolitis hypersensitiva e pulvere organico

Similar endpoints

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List of similar endpoints to Hypersensitivity pneumonitis due to organic dust based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	358	185	173
Unadjusted prevalence (%)	0.12	0.11	0.13
Mean age at first event (years)	45.94	45.11	46.83

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	1.05 [0.36, 3.04]	9.2e-1	49
15 years	0.01	0.85 [0.32, 2.27]	7.4e-1	23
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust
GWS hits: 0

Survival analyses between endpoints

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Plot

before Hypersensitivity pneumonitis due to organic dust
after Hypersensitivity pneumonitis due to organic dust

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Table

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Drugs most likely to be purchased after Hypersensitivity pneumonitis due to organic dust

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