Vascular dementia

I9_VASCDEM

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F01

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 F01

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1609

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1609

Check minimum number of events None

1609

Include endpoints None

1609

I9_VASCDEM

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 F00-F03

Name in latin Dementia vascularis

Similar endpoints

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List of similar endpoints to Vascular dementia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1560	553	1007
Unadjusted prevalence (%)	0.51	0.32	0.75
Mean age at first event (years)	79.07	81.68	77.64

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.15	11.81 [10.09, 13.81]	<1e-100	1005
15 years	0.01	2.09 [1.74, 2.50]	3.3e-15	162
5 years	0.01	6.98 [5.90, 8.27]	<1e-100	393
1 year	0.00	24.57 [20.79, 29.03]	<1e-100	446

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_VASCDEM – Vascular dementia
GWS hits: 1

Survival analyses between endpoints

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Plot

before Vascular dementia
after Vascular dementia

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Table

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Drugs most likely to be purchased after Vascular dementia

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