Rheumatic fever incl heart disease

I9_RHEUFEV

rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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I9_RHEUFEV

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Rheumatic fever incl heart disease based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

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Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 808 385 423
Unadjusted prevalence (%) 0.26 0.22 0.31
Mean age at first event (years) 49.04 47.21 50.71

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.39 [1.53, 3.71] 1.1e-4 255
15 years 0.01 1.43 [0.98, 2.08] 6.1e-2 109
5 years 0.00 2.13 [1.51, 3.01] 1.8e-5 49
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_RHEUFEV – Rheumatic fever incl heart disease
GWS hits: 1

Survival analyses between endpoints

Plot

before Rheumatic fever incl heart disease
after Rheumatic fever incl heart disease

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Drugs most likely to be purchased after Rheumatic fever incl heart disease