Rheumatic fever without mention of heart involvement

I9_RHEUFEVWITHOUTHEART

rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I00, I00+J17.8, I00+L54.0, I02.9

Hospital discharge: ICD-9 390

Hospital discharge: ICD-8 390

Cause of death: ICD-10 I00, I00+J17.8, I00+L54.0, I02.9

Cause of death: ICD-9 390

Cause of death: ICD-8 390

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

I9_RHEUFEVWITHOUTHEART

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Rheumatic fever without mention of heart involvement based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	80	41	39
Unadjusted prevalence (%)	0.03	0.02	0.03
Mean age at first event (years)	32.69	31.21	34.25

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_RHEUFEVWITHOUTHEART – Rheumatic fever without mention of heart involvement
GWS hits:

Survival analyses between endpoints

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Plot

before Rheumatic fever without mention of heart involvement
after Rheumatic fever without mention of heart involvement

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Table

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Drugs most likely to be purchased after Rheumatic fever without mention of heart involvement

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