Progressive vascular leukoencephalopathy

DOID EFO MESH PheWeb

I9_PROGVASC

brain aneurysm: A congenital or acquired aneurysm within the cranium.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I67.3

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 I67.3

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

468

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

468

Check minimum number of events None

468

Include endpoints None

468

I9_PROGVASC

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 I67

Name in latin Leucoencephalopathia vascularis progressiva

Similar endpoints

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List of similar endpoints to Progressive vascular leukoencephalopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	452	236	216
Unadjusted prevalence (%)	0.15	0.14	0.16
Mean age at first event (years)	76.45	76.40	76.50

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.13 [3.57, 10.54]	4.9e-11	100
15 years	0.01	1.90 [1.14, 3.17]	1.4e-2	27
5 years	0.01	5.04 [3.23, 7.88]	1.2e-12	44
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_PROGVASC – Progressive vascular leukoencephalopathy
GWS hits: 0

Survival analyses between endpoints

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Plot

before Progressive vascular leukoencephalopathy
after Progressive vascular leukoencephalopathy

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Table

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Drugs most likely to be purchased after Progressive vascular leukoencephalopathy

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