Peripheral artery disease

I9_PAD

peripheral arterial disease: A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E10.5, E10.5+I79.2, E11.5, E11.5+I79.2, E12.5, E13.5, E14.5, I70.2, I73.9

Hospital discharge: ICD-9 4402|4439

Hospital discharge: ICD-8 25006|4402|4439

Cause of death: ICD-10 E10.5, E10.5+I79.2, E11.5, E11.5+I79.2, E12.5, E13.5, E14.5, I70.2, I73.9

Cause of death: ICD-9 4402|4439

Cause of death: ICD-8 25006|4402|4439

11637

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

11637

Check minimum number of events None

11637

Include endpoints

I9_PERIPH

12253

I9_PAD

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Peripheral artery disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	11924	3787	8137
Unadjusted prevalence (%)	3.86	2.18	6.03
Mean age at first event (years)	66.29	66.48	66.20

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.58 [3.84, 5.47]	3.0e-63	4099
15 years	0.01	2.40 [2.08, 2.77]	6.8e-33	1710
5 years	0.01	4.61 [4.16, 5.12]	<1e-100	1365
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_PAD – Peripheral artery disease
GWS hits: 1

Survival analyses between endpoints

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Plot

before Peripheral artery disease
after Peripheral artery disease

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Table

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Drugs most likely to be purchased after Peripheral artery disease

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