Cerebral amyloid angiopathy


cerebral amyloid angiopathy: Hereditary cerebral hemorrhage with amyloidosis (HCHWA) describes a group of rare familial central nervous system disorders characterized by amyloid deposition in the cerebral blood vessels leading to hemorrhagic and non-hemorrhagic strokes, focal neurological deficits, and progressive cognitive decline eventually leading to dementia.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 I68.0*, I68.0*E85.9
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 I68.0*, I68.0*E85.9
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 45 18 27
Unadjusted prevalence (%) 0.01 0.01 0.02
Mean age at first event (years) 67.96 64.40 70.34


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_CEREBAMY – Cerebral amyloid angiopathy
GWS hits:

Survival analyses between endpoints


before Cerebral amyloid angiopathy
after Cerebral amyloid angiopathy

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Drugs most likely to be purchased after Cerebral amyloid angiopathy