Diseases of inner ear

H8_INNER

vestibular disease: Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls. [database_cross_reference: MESH:D015837]

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H80-H83

Cause of death: ICD-10 H80-H83

13582

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

13582

Check minimum number of events None

13582

Include endpoints

H8_OTOSCLE

H8_VERTIGO

H8_LABYRINTHITIS

H8_LABYRFISTU

H8_LABYRDYSFUNC

H8_NOISEINNER

H8_INNERNAS

14343

H8_INNER

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diseases of inner ear based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	13874	8547	5327
Unadjusted prevalence (%)	4.50	4.93	3.95
Mean age at first event (years)	55.95	55.00	57.47

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	1.12 [0.91, 1.39]	2.9e-1	960
15 years	0.00	0.78 [0.64, 0.94]	1.1e-2	472
5 years	0.00	1.49 [1.24, 1.79]	1.9e-5	255
1 year	0.00	1.93 [1.45, 2.57]	7.7e-6	63

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_INNER – Diseases of inner ear
GWS hits: 2

Survival analyses between endpoints

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Plot

before Diseases of inner ear
after Diseases of inner ear

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Table

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Drugs most likely to be purchased after Diseases of inner ear

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