Otosclerosis

H8_OTOSCLE

otosclerosis: Formation of spongy bone in the labyrinth capsule which can progress toward the stapes (stapedial fixation) or anteriorly toward the cochlea leading to conductive, sensorineural, or mixed hearing loss. Several genes are associated with familial otosclerosis with varied clinical signs.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H80

Hospital discharge: ICD-9 387

Hospital discharge: ICD-8 38699

Cause of death: ICD-10 H80

Cause of death: ICD-9 387

Cause of death: ICD-8 38699

2508

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1958

Check minimum number of events None

1958

Include endpoints None

1958

H8_OTOSCLE

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H80-H83

Name in latin Otosclerosis

Similar endpoints

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List of similar endpoints to Otosclerosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1887	1213	674
Unadjusted prevalence (%)	0.61	0.70	0.50
Mean age at first event (years)	45.85	44.85	47.65

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.80 [0.53, 1.20]	2.8e-1	135
15 years	0.00	0.64 [0.43, 0.95]	2.8e-2	63
5 years	0.00	1.00 [0.62, 1.62]	1.0e+0	22
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_OTOSCLE – Otosclerosis
GWS hits: 13

Survival analyses between endpoints

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Plot

before Otosclerosis
after Otosclerosis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Otosclerosis

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