Ménière disease

H8_MENIERE

endolymphatic hydrops: An accumulation of endolymph in the inner ear (labyrinth) leading to buildup of pressure and distortion of intralabyrinthine structures, such as cochlea and semicircular canals. It is characterized by sensorineural hearing loss; tinnitus; and sometimes vertigo.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H81.0

Hospital discharge: ICD-9 3860

Hospital discharge: ICD-8 38599

Cause of death: ICD-10 H81.0

Cause of death: ICD-9 3860

Cause of death: ICD-8 38599

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

2273

H8_MENIERE

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H81

Name in latin Morbus Ménière

Similar endpoints

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List of similar endpoints to Ménière disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2211	1451	760
Unadjusted prevalence (%)	0.72	0.84	0.56
Mean age at first event (years)	55.46	54.48	57.35

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.87 [0.45, 1.68]	6.8e-1	158
15 years	0.00	0.62 [0.35, 1.10]	1.0e-1	73
5 years	0.00	1.35 [0.78, 2.32]	2.8e-1	35
1 year	0.00	2.18 [1.03, 4.59]	4.1e-2	10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H8_MENIERE – Ménière disease
GWS hits: 1

Survival analyses between endpoints

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Plot

before Ménière disease
after Ménière disease

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Table

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Drugs most likely to be purchased after Ménière disease

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