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Vascular syndromes of brain in cerebrovascular disorders

DOIDEFOMESHSNOMED PheWeb

G6_VASCSYND

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 G46*
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 G46*
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

933

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

933

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Check minimum number of events None

933

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Include endpoints None

933

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G6_VASCSYND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 903 362 541
Unadjusted prevalence (%) 0.29 0.21 0.40
Mean age at first event (years) 66.39 65.23 67.16

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 5.95 [4.22, 8.39] 2.4e-24 224
15 years 0.02 2.60 [1.82, 3.71] 1.6e-7 94
5 years 0.00 4.47 [3.28, 6.09] 1.8e-21 78
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_VASCSYND – Vascular syndromes of brain in cerebrovascular disorders
GWS hits: 0

Survival analyses between endpoints

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Plot

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Drugs most likely to be purchased after Vascular syndromes of brain in cerebrovascular disorders

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