Normal-pressure hydrocephalus

G6_HCNP

normal pressure hydrocephalus: A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see gait disorders, neurologic), progressive intellectual decline, and urinary incontinence. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of csf including subarachnoid hemorrhage, chronic meningitis, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G91.2

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 G91.2

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

547

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

547

Check minimum number of events None

547

Include endpoints None

547

G6_HCNP

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G91

Name in latin Hydrocephalia normotensiva

Similar endpoints

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List of similar endpoints to Normal-pressure hydrocephalus based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	534	237	297
Unadjusted prevalence (%)	0.17	0.14	0.22
Mean age at first event (years)	69.76	69.11	70.27

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_HCNP – Normal-pressure hydrocephalus
GWS hits: 1

Survival analyses between endpoints

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Plot

before Normal-pressure hydrocephalus
after Normal-pressure hydrocephalus

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Table

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Drugs most likely to be purchased after Normal-pressure hydrocephalus

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