Toxic encephalopathy

G6_ENCEPHTOX

toxic encephalopathy: A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G92

Hospital discharge: ICD-9 3498B

Hospital discharge: ICD-8 32302

Cause of death: ICD-10 G92

Cause of death: ICD-9 3498B

Cause of death: ICD-8 32302

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

G6_ENCEPHTOX

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G90-G99

Name in latin Encephalopathia toxica

Similar endpoints

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List of similar endpoints to Toxic encephalopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

Unadjusted prevalence (%)

0.02

0.01

0.03

Mean age at first event (years)

54.68

50.20

55.69

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_ENCEPHTOX – Toxic encephalopathy
GWS hits:

Survival analyses between endpoints

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Plot

before Toxic encephalopathy
after Toxic encephalopathy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Toxic encephalopathy

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