Schizophrenia

F5_SCHZPHR

schizophrenia: A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 F20
Hospital discharge: ICD-9 295
Hospital discharge: ICD-8 295
Hospital discharge: excluded ICD-9 2954|2957
Hospital discharge: excluded ICD-8 2957
Cause of death: ICD-10 F20
Cause of death: ICD-9 295
Cause of death: ICD-8 295
Cause of death: excluded ICD-9 2954|2957
Cause of death: excluded ICD-8 2957

6351

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6287

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Check minimum number of events None

6287

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Include endpoints None

6287

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F5_SCHZPHR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F20-F29
Name in latin Schizophrenia

Summary Statistics

Key figures

All Female Male
Number of individuals 6050 2722 3328
Unadjusted prevalence (%) 1.96 1.57 2.46
Mean age at first event (years) 32.02 33.15 31.09

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.50 [1.83, 3.43] 1.1e-8 400
15 years 0.01 1.62 [1.20, 2.17] 1.5e-3 152
5 years 0.00 2.34 [1.69, 3.25] 3.7e-7 52
1 year 0.00 4.36 [2.63, 7.24] 1.2e-8 18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: F5_SCHZPHR – Schizophrenia
GWS hits: 0

Survival analyses between endpoints

Plot

before Schizophrenia
after Schizophrenia

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