Primary ovarian failure


primary ovarian insufficiency: Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule

Sex only females


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E28.3
Hospital discharge: ICD-9 2563
Hospital discharge: ICD-8 2561
Cause of death: ICD-10 E28.3
Cause of death: ICD-9 2563
Cause of death: ICD-8 2561
KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 E28.3


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E28
Name in latin Insufficientia ovariorum primaria

Summary Statistics

Key figures

All Female Male
Number of individuals 328 328 -
Unadjusted prevalence (%) 0.11 0.19 -
Mean age at first event (years) 35.14 35.14 -


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_OVARFAIL – Primary ovarian failure
GWS hits: 0

Survival analyses between endpoints


before Primary ovarian failure
after Primary ovarian failure

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Drugs most likely to be purchased after Primary ovarian failure