Primary ovarian failure

E4_OVARFAIL

primary ovarian insufficiency: Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule

Sex only females

180574

Check conditions None

180574

Filter registries

Hospital Discharge: ICD-10 E28.3

Hospital discharge: ICD-9 2563

Hospital discharge: ICD-8 2561

Cause of death: ICD-10 E28.3

Cause of death: ICD-9 2563

Cause of death: ICD-8 2561

KELA reimbursements: KELA codes ANY

KELA reimbursements: ICD-10 E28.3

87524

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

347

Check minimum number of events None

347

Include endpoints None

347

E4_OVARFAIL

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E28

Name in latin Insufficientia ovariorum primaria

Similar endpoints

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List of similar endpoints to Primary ovarian failure based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	328	328	-
Unadjusted prevalence (%)	0.11	0.19	-
Mean age at first event (years)	35.14	35.14	-

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_OVARFAIL – Primary ovarian failure
GWS hits: 0

Survival analyses between endpoints

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Plot

before Primary ovarian failure
after Primary ovarian failure

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Table

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Drugs most likely to be purchased after Primary ovarian failure

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