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Hypopituitarism

DOIDEFOMESHSNOMED PheWeb

E4_HYPOPIT

hypopituitarism: A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Hospital discharge: ICD-9 2532
Hospital discharge: ICD-8 2531
Cause of death: ICD-10 E23.00, E23.01, E23.02, E23.03, E23.04, E23.05, E23.06, E23.08, E23.09
Cause of death: ICD-9 2532
Cause of death: ICD-8 2531
KELA reimbursements: KELA codes 101

1415

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1384

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Check minimum number of events None

1384

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Include endpoints None

1384

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E4_HYPOPIT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1339 496 843
Unadjusted prevalence (%) 0.43 0.29 0.62
Mean age at first event (years) 43.56 41.99 44.48

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.64 [0.60, 4.44] 3.3e-1 71
15 years 0.01 0.92 [0.39, 2.16] 8.4e-1 25
5 years 0.00 3.37 [1.70, 6.69] 5.0e-4 23
1 year 0.00 7.76 [3.46, 17.41] 6.8e-7 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPOPIT – Hypopituitarism
GWS hits: 3

Survival analyses between endpoints

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Plot

before Hypopituitarism
after Hypopituitarism

loading spinner Loading survival analyses plot