Hypoparathyroidism

E4_HYPOPARA

hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E20

Hospital discharge: ICD-9 2521

Hospital discharge: ICD-8 2521

Cause of death: ICD-10 E20

Cause of death: ICD-9 2521

Cause of death: ICD-8 2521

KELA reimbursements: KELA codes 106

Medicine purchases: ATC H05AA

755

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

731

Check minimum number of events

Min. number of events 3

731

Include endpoints None

731

E4_HYPOPARA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E20-E35

Name in latin Hypoparathyreoidismus

Similar endpoints

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List of similar endpoints to Hypoparathyroidism based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	709	559	150
Unadjusted prevalence (%)	0.23	0.32	0.11
Mean age at first event (years)	55.53	55.26	56.54

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.52 [1.16, 5.48]	1.9e-2	58
15 years	0.00	0.78 [0.35, 1.75]	5.4e-1	13
5 years	0.00	3.50 [1.72, 7.11]	5.3e-4	22
1 year	0.00	8.33 [3.76, 18.45]	1.7e-7	10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPOPARA – Hypoparathyroidism
GWS hits: 1

Survival analyses between endpoints

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Plot

before Hypoparathyroidism
after Hypoparathyroidism

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Table

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Drugs most likely to be purchased after Hypoparathyroidism

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