Hyperparathyroidism

E4_HYPERPARA

hyperparathyroidism: Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 E21.09, E21.1, E21.2, E21.3
Hospital discharge: ICD-9 2520
Hospital discharge: ICD-8 2520
Cause of death: ICD-10 E21.09, E21.1, E21.2, E21.3
Cause of death: ICD-9 2520
Cause of death: ICD-8 2520
Medicine purchases: ATC H05B

6709

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4520

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Check minimum number of events

Min. number of events 3

4520

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Include endpoints None

4520

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E4_HYPERPARA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 4386 3246 1140
Unadjusted prevalence (%) 1.42 1.87 0.84
Mean age at first event (years) 63.12 63.08 63.25

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.25 [1.62, 3.13] 1.2e-6 898
15 years 0.01 1.48 [1.15, 1.90] 2.2e-3 449
5 years 0.00 2.51 [2.09, 3.01] 6.8e-23 273
1 year 0.00 3.66 [2.81, 4.77] 5.5e-22 80

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_HYPERPARA – Hyperparathyroidism
GWS hits: 2

Survival analyses between endpoints

Plot

before Hyperparathyroidism
after Hyperparathyroidism

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Drugs most likely to be purchased after Hyperparathyroidism