Hyperparathyroidism

E4_HYPERPARA

hyperparathyroidism: Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E21.09, E21.1, E21.2, E21.3

Hospital discharge: ICD-9 2520

Hospital discharge: ICD-8 2520

Cause of death: ICD-10 E21.09, E21.1, E21.2, E21.3

Cause of death: ICD-9 2520

Cause of death: ICD-8 2520

Medicine purchases: ATC H05B

6709

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4520

Check minimum number of events

Min. number of events 3

4520

Include endpoints None

4520

E4_HYPERPARA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Hyperparathyroidism based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4386	3246	1140
Unadjusted prevalence (%)	1.42	1.87	0.84
Mean age at first event (years)	63.12	63.08	63.25

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.25 [1.62, 3.13]	1.2e-6	898
15 years	0.01	1.48 [1.15, 1.90]	2.2e-3	449
5 years	0.00	2.51 [2.09, 3.01]	6.8e-23	273
1 year	0.00	3.66 [2.81, 4.77]	5.5e-22	80

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERPARA – Hyperparathyroidism
GWS hits: 2

Survival analyses between endpoints

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Plot

before Hyperparathyroidism
after Hyperparathyroidism

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Table

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Drugs most likely to be purchased after Hyperparathyroidism

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