Adrenocortical insufficiency

DOID MESH PheWeb

E4_ADDISON

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E27.1, E27.2, E27.3#, E27.4

Hospital discharge: ICD-9 2554

Hospital discharge: ICD-8 2551

Cause of death: ICD-10 E27.1, E27.2, E27.3#, E27.4

Cause of death: ICD-9 2554

Cause of death: ICD-8 2551

KELA reimbursements: KELA codes 105

713

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

685

Check minimum number of events None

685

Include endpoints None

685

E4_ADDISON

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Adrenocortical insufficiency based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Drug-induced adrenocortical insufficiency

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	667	448	219
Unadjusted prevalence (%)	0.22	0.26	0.16
Mean age at first event (years)	49.19	48.35	50.91

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.45 [3.55, 11.72]	9.5e-10	68
15 years	0.01	2.33 [1.18, 4.61]	1.5e-2	23
5 years	0.01	5.11 [2.53, 10.32]	5.4e-6	21
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_ADDISON – Adrenocortical insufficiency
GWS hits: 1

Survival analyses between endpoints

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Plot

before Adrenocortical insufficiency
after Adrenocortical insufficiency

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Table

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Drugs most likely to be purchased after Adrenocortical insufficiency

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