Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function

D3_CVID_TCELL

obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D83.1

Hospital discharge: ICD-9 2791X

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 D83.1

Cause of death: ICD-9 2791X

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

D3_CVID_TCELL

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D83

Name in latin Deficientia immunalis variabilis communis praecipue cum abnormalitatibus cellularum T immunoregulatoriarum

Similar endpoints

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List of similar endpoints to Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	29	21	8
Unadjusted prevalence (%)	0.01	0.01	0.01
Mean age at first event (years)	55.71	55.59	56.05

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_CVID_TCELL – Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function
GWS hits:

Survival analyses between endpoints

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before Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function
after Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function

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Drugs most likely to be purchased after Common variable immunodeficiency with predominant abnormalities of T-cell numbers and function

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