Other coagulation defects

D3_COAGOTHER

thrombophilia: A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 D68

Cause of death: ICD-10 D68

1461

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

1461

Check minimum number of events None

1461

Include endpoints

D3_VONVILLEBRAND

D3_HEREDFXIDEF

D3_HEREDOTHCLOFACTORS

D3_HAEMORRHAGCIRGUANTICO

D3_ACQCOAFACDEF

D3_PRIMTHROMBOPHILIA

D3_OTHTHROMBOPHILIA

D3_COAGDEFNAS

1490

D3_COAGOTHER

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 D65-D69

Name in latin Aliae defectus coagulationis

Similar endpoints

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List of similar endpoints to Other coagulation defects based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1430	964	466
Unadjusted prevalence (%)	0.46	0.56	0.35
Mean age at first event (years)	48.97	44.93	57.33

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.68 [2.27, 9.65]	2.9e-5	187
15 years	0.01	0.90 [0.42, 1.92]	7.9e-1	29
5 years	0.00	2.25 [1.12, 4.50]	2.3e-2	25
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: D3_COAGOTHER – Other coagulation defects
GWS hits: 10

Survival analyses between endpoints

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Plot

before Other coagulation defects
after Other coagulation defects

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other coagulation defects

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