Congenital malformations of heart and great arteries

DOID MESH PheWeb

CONGEN_HEART_ARTER

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 Q20, Q21, Q22, Q23, Q24, Q25

Hospital discharge: ICD-9 745|746|747[0-3]

Hospital discharge: ICD-8 746|747[0-3]

Cause of death: ICD-10 Q20, Q21, Q22, Q23, Q24, Q25

Cause of death: ICD-9 745|746|747[0-3]

Cause of death: ICD-8 746|747[0-3]

3860

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3165

Check minimum number of events None

3165

Include endpoints None

3165

CONGEN_HEART_ARTER

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Congenital malformations of heart and great arteries based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3024	1582	1442
Unadjusted prevalence (%)	0.98	0.91	1.07
Mean age at first event (years)	30.65	28.05	33.50

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.39 [1.50, 3.82]	2.7e-4	149
15 years	0.01	1.65 [1.06, 2.56]	2.7e-2	64
5 years	0.00	3.45 [2.23, 5.33]	2.7e-8	33
1 year	0.00	9.90 [5.77, 16.99]	8.9e-17	18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CONGEN_HEART_ARTER – Congenital malformations of heart and great arteries
GWS hits: 1

Survival analyses between endpoints

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Plot

before Congenital malformations of heart and great arteries
after Congenital malformations of heart and great arteries

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Table

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Drugs most likely to be purchased after Congenital malformations of heart and great arteries

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