Brain glioblastoma

C3_GBM

brain glioblastoma: A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

HLP_C3_GBM

171

Filter registries

Cause of death: ICD-10 C71

Cause of death: ICD-9 191

Cause of death: ICD-8 191

Cancer registry: Topography ICD-O-3 C71

Cancer registry: Morphology ICD-O-3 9440

Cancer registry: Behaviour codes 3

171

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

171

Check minimum number of events None

171

Include endpoints None

171

C3_GBM

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF4

Similar endpoints

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List of similar endpoints to Brain glioblastoma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	155	68	87
Unadjusted prevalence (%)	0.05	0.04	0.06
Mean age at first event (years)	63.67	64.38	63.11

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_GBM – Brain glioblastoma
GWS hits: 0

Survival analyses between endpoints

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Plot

before Brain glioblastoma
after Brain glioblastoma

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Table

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Drugs most likely to be purchased after Brain glioblastoma

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