Childhood asthma (age<16)

ASTHMA_CHILD

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493
Cause of death: ICD-10 J45, J46
Cause of death: ICD-9 493
Cause of death: ICD-8 493

33507

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Check pre-conditions, main-only, mode, ICD version

Pre-conditions EVENT_AGE<16
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4743

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Check minimum number of events None

4743

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Include endpoints None

4743

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ASTHMA_CHILD

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
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Number of individuals
4549 2637 1912
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Unadjusted prevalence (%)
1.47 1.52 1.42
?
Mean age at first event (years)
7.42 7.95 6.68

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Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 6.47 [3.66, 11.43] 1.2e-10 24
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ASTHMA_CHILD – Childhood asthma (age<16)
GWS hits: 9

Survival analyses between endpoints

Plot

before Childhood asthma (age<16)
after Childhood asthma (age<16)

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Drugs most likely to be purchased after Childhood asthma (age<16)