Acute appendicitis, with complications

DOID EFO MESH SNOMED PheWeb

APPENDACUT_COMPLIC

appendicitis: Acute inflammation of the vermiform appendix.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K35.0, K35.1

Hospital discharge: ICD-9 540[0-1]

Hospital discharge: ICD-8 540

Hospital discharge: excluded ICD-8 54090|54099

Cause of death: ICD-10 K35.0, K35.1

Cause of death: ICD-9 540[0-1]

Cause of death: ICD-8 540

Cause of death: excluded ICD-8 54090|54099

9423

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5560

Check minimum number of events None

5560

Include endpoints None

5560

APPENDACUT_COMPLIC

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Acute appendicitis, with complications based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5409	2586	2823
Unadjusted prevalence (%)	1.75	1.49	2.09
Mean age at first event (years)	35.94	33.92	37.80

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.41 [1.09, 1.82]	7.8e-3	484
15 years	0.01	0.99 [0.79, 1.25]	9.5e-1	220
5 years	0.00	1.42 [1.08, 1.85]	1.1e-2	80
1 year	0.00	2.50 [1.64, 3.80]	1.9e-5	26

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications
GWS hits: 1

Survival analyses between endpoints

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Plot

before Acute appendicitis, with complications
after Acute appendicitis, with complications

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Table

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Drugs most likely to be purchased after Acute appendicitis, with complications

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