Alcohol-induced chronic pancreatitis

ALCOPANCCHRON

alcoholic pancreatitis: Acute or chronic inflammation of the pancreas due to excessive alcohol drinking. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K86.00, K86.01, K86.08

Hospital discharge: ICD-9 5771C|5771D

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K86.00, K86.01, K86.08

Cause of death: ICD-9 5771C|5771D

Cause of death: ICD-8 $!$

1457

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1457

Check minimum number of events None

1457

Include endpoints None

1457

ALCOPANCCHRON

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Alcohol-induced chronic pancreatitis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1425	324	1101
Unadjusted prevalence (%)	0.46	0.19	0.82
Mean age at first event (years)	50.40	48.52	50.95

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.87 [3.16, 7.51]	8.0e-13	246
15 years	0.02	3.47 [2.34, 5.15]	6.5e-10	119
5 years	0.01	5.01 [3.39, 7.40]	6.4e-16	46
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ALCOPANCCHRON – Alcohol-induced chronic pancreatitis
GWS hits: 3

Survival analyses between endpoints

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Plot

before Alcohol-induced chronic pancreatitis
after Alcohol-induced chronic pancreatitis

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Table

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Drugs most likely to be purchased after Alcohol-induced chronic pancreatitis

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