Other diseases of oesophagus

K11_OTHDISOES

esophageal disease: A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K22.4, K22.5, K22.6, K22.7, K22.8, K22.9

Hospital discharge: ICD-9 530[5-9]

Hospital discharge: ICD-8 5302|5309

Hospital discharge: excluded ICD-10 K22.7

Cause of death: ICD-10 K22.4, K22.5, K22.6, K22.7, K22.8, K22.9

Cause of death: ICD-9 530[5-9]

Cause of death: ICD-8 5302|5309

2397

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2377

Check minimum number of events None

2377

Include endpoints None

2377

K11_OTHDISOES

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other diseases of oesophagus based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2312	1011	1301
Unadjusted prevalence (%)	0.75	0.58	0.96
Mean age at first event (years)	54.02	52.29	55.37

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.09 [1.55, 2.83]	1.5e-6	409
15 years	0.01	1.17 [0.88, 1.56]	2.7e-1	172
5 years	0.00	2.33 [1.76, 3.07]	2.3e-9	107
1 year	0.00	4.31 [2.93, 6.33]	9.3e-14	38

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_OTHDISOES – Other diseases of oesophagus
GWS hits: 1

Survival analyses between endpoints

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Plot

before Other diseases of oesophagus
after Other diseases of oesophagus

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Table

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Drugs most likely to be purchased after Other diseases of oesophagus

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