Asthma (only as main-diagnosis)

J10_ASTHMA_MAIN

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J45, J46

Hospital discharge: ICD-9 493

Hospital discharge: ICD-8 493

Cause of death: ICD-10 J45, J46

Cause of death: ICD-9 493

Cause of death: ICD-8 493

33507

Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

27298

Check minimum number of events None

27298

Include endpoints None

27298

J10_ASTHMA_MAIN

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Asthma (only as main-diagnosis) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	26363	16387	9976
Unadjusted prevalence (%)	8.54	9.44	7.39
Mean age at first event (years)	42.22	41.30	43.73

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.71 [1.46, 2.01]	3.2e-11	2317
15 years	0.01	1.23 [1.07, 1.41]	4.0e-3	1123
5 years	0.00	2.01 [1.75, 2.33]	1.0e-21	536
1 year	0.00	3.13 [2.56, 3.83]	1.6e-28	159

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_ASTHMA_MAIN – Asthma (only as main-diagnosis)
GWS hits: 27

Survival analyses between endpoints

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Plot

before Asthma (only as main-diagnosis)
after Asthma (only as main-diagnosis)

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Table

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Drugs most likely to be purchased after Asthma (only as main-diagnosis)

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