Ischaemic heart disease, wide definition

I9_IHD

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I20-I25

Hospital discharge: ICD-9 41[0-4]

Hospital discharge: ICD-8 41[0-4]

Cause of death: ICD-10 I21, I22, I23, I24, I25, I46, R96, R98

Cause of death: ICD-9 41[0-4]|798

Cause of death: ICD-8 41[0-4]|798

Cause of death: excluded ICD-9 7980A

KELA reimbursements: KELA codes 206

50277

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

50277

Check minimum number of events None

50277

Include endpoints None

50277

I9_IHD

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Ischaemic heart disease, wide definition based on the number of shared cases.

Broader endpoints:

None

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	48706	16882	31824
Unadjusted prevalence (%)	15.79	9.73	23.57
Mean age at first event (years)	63.41	64.46	62.86

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.85 [3.54, 4.18]	<1e-100	14094
15 years	0.01	2.19 [2.01, 2.38]	3.4e-72	5536
5 years	0.00	3.43 [3.16, 3.73]	<1e-100	2744
1 year	0.00	26.30 [23.27, 29.73]	<1e-100	3906

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_IHD – Ischaemic heart disease, wide definition
GWS hits: 42

Survival analyses between endpoints

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Plot

before Ischaemic heart disease, wide definition
after Ischaemic heart disease, wide definition

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Table

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Drugs most likely to be purchased after Ischaemic heart disease, wide definition

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