Other disorders of nervous system

G6_NEUROOTH

nervous system disease: A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G98, G99*

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 G98, G99*

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1330

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1330

Check minimum number of events None

1330

Include endpoints None

1330

G6_NEUROOTH

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other disorders of nervous system based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Diabetic autonomic neuropathy

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1295	640	655
Unadjusted prevalence (%)	0.42	0.37	0.49
Mean age at first event (years)	58.03	56.07	59.95

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.75 [2.56, 5.50]	1.3e-11	111
15 years	0.01	1.96 [1.29, 2.98]	1.7e-3	52
5 years	0.00	3.51 [2.01, 6.13]	1.0e-5	38
1 year	0.00	5.96 [2.89, 12.28]	1.3e-6	13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_NEUROOTH – Other disorders of nervous system
GWS hits: 0

Survival analyses between endpoints

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Plot

before Other disorders of nervous system
after Other disorders of nervous system

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Table

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Drugs most likely to be purchased after Other disorders of nervous system

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