Thyrotoxicosis with diffuse goitre

E4_THYTOXGOITDIF

Graves disease: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland ( hyperthyroidism ).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy , antithyroid drugs, and/or thyroid surgery.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E05.0

Hospital discharge: ICD-9 2420

Hospital discharge: ICD-8 2420

Cause of death: ICD-10 E05.0

Cause of death: ICD-9 2420

Cause of death: ICD-8 2420

3574

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3574

Check minimum number of events None

3574

Include endpoints None

3574

E4_THYTOXGOITDIF

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E05

Name in latin Thyreotoxicosis cum struma diffusa

Similar endpoints

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List of similar endpoints to Thyrotoxicosis with diffuse goitre based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Autoimmune hyperthyroidism

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3467	2894	573
Unadjusted prevalence (%)	1.12	1.67	0.42
Mean age at first event (years)	48.83	48.07	52.68

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.61 [1.01, 2.55]	4.4e-2	128
15 years	0.01	1.04 [0.61, 1.75]	9.0e-1	61
5 years	0.00	1.46 [0.79, 2.68]	2.2e-1	27
1 year	0.00	4.45 [2.26, 8.76]	1.5e-5	15

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYTOXGOITDIF – Thyrotoxicosis with diffuse goitre
GWS hits: 10

Survival analyses between endpoints

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Plot

before Thyrotoxicosis with diffuse goitre
after Thyrotoxicosis with diffuse goitre

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Table

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Drugs most likely to be purchased after Thyrotoxicosis with diffuse goitre

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