Diabetic polyneuropathy

DM_POLYNEURO

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G63.2*E10.4, G63.2*E11.4

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 G63.2*E10.4, G63.2*E11.4

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

853

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

829

Check minimum number of events None

829

Include endpoints None

829

DM_POLYNEURO

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

↥

List of similar endpoints to Diabetic polyneuropathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	805	298	507
Unadjusted prevalence (%)	0.26	0.17	0.38
Mean age at first event (years)	58.98	56.70	60.32

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.10	8.13 [5.60, 11.82]	4.2e-28	147
15 years	0.02	3.66 [2.45, 5.45]	2.1e-10	64
5 years	0.01	6.97 [4.64, 10.47]	8.8e-21	51
1 year	0.00	12.42 [7.39, 20.88]	2.1e-21	20

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: DM_POLYNEURO – Diabetic polyneuropathy
GWS hits: 0

Survival analyses between endpoints

↥

Plot

before Diabetic polyneuropathy
after Diabetic polyneuropathy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Diabetic polyneuropathy

↥