Vocal cord dysfunction

VOCALCORDDYS

human african trypanosomiasis: A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J38.3

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 J38.3

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

823

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

823

Check minimum number of events None

823

Include endpoints None

823

VOCALCORDDYS

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 J38

Name in latin Alii morbi plicarum vocalium

Similar endpoints

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List of similar endpoints to Vocal cord dysfunction based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	795	380	415
Unadjusted prevalence (%)	0.26	0.22	0.31
Mean age at first event (years)	55.41	52.61	57.97

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	1.16 [0.35, 3.84]	8.0e-1	59
15 years	0.01	0.88 [0.32, 2.42]	8.0e-1	26
5 years	0.00	2.94 [1.34, 6.43]	6.9e-3	22
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: VOCALCORDDYS – Vocal cord dysfunction
GWS hits: 0

Survival analyses between endpoints

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Plot

before Vocal cord dysfunction
after Vocal cord dysfunction

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Table

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Drugs most likely to be purchased after Vocal cord dysfunction

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