Craniosynostosis EXCLUDE syndromes

PheWeb

Q17_CRANIOSYNOSTOSIS

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not Q17_SYNDROMATA_MALFORMATIONUM_CONGENITAR_PRAECI_FACIEM_AFFIC1

321232

Filter registries

Hospital Discharge: ICD-10 Q75.0

Hospital discharge: ICD-9 7560A

Hospital discharge: ICD-8 756

Cause of death: ICD-10 Q75.0

Cause of death: ICD-9 7560A

Cause of death: ICD-8 756

778

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

604

Check minimum number of events None

604

Include endpoints None

604

Q17_CRANIOSYNOSTOSIS

Extra metadata

First used in FinnGen datafreeze DF7

Similar endpoints

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List of similar endpoints to Craniosynostosis EXCLUDE syndromes based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	586	287	299
Unadjusted prevalence (%)	0.19	0.17	0.22
Mean age at first event (years)	24.58	23.38	25.74

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.69 [0.30, 1.58]	3.8e-1	68
15 years	0.00	0.52 [0.24, 1.15]	1.0e-1	28
5 years	0.00	0.90 [0.38, 2.12]	8.1e-1	10
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: Q17_CRANIOSYNOSTOSIS – Craniosynostosis EXCLUDE syndromes
GWS hits: 0

Survival analyses between endpoints

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Plot

before Craniosynostosis EXCLUDE syndromes
after Craniosynostosis EXCLUDE syndromes

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Table

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Drugs most likely to be purchased after Craniosynostosis EXCLUDE syndromes

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