Cleft lip, lip and palate or palate

Q17_CLEFT_LIP_CLEFT_PALATE

cleft lip: ['Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not Q17_CLEFT_PALATE_EXCLUDE

320838

Filter registries

Hospital Discharge: ICD-10 Q35-Q37

Hospital discharge: ICD-9 749

Hospital discharge: ICD-8 74900|74910|74911|74912|74913|74920|74924|74929

Cause of death: ICD-10 Q35-Q37

Cause of death: ICD-9 749

Cause of death: ICD-8 74900|74910|74911|74912|74913|74920|74924|74929

377

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

370

Check minimum number of events None

370

Include endpoints None

370

Q17_CLEFT_LIP_CLEFT_PALATE

Extra metadata

First used in FinnGen datafreeze DF7

Similar endpoints

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List of similar endpoints to Cleft lip, lip and palate or palate based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	355	212	143
Unadjusted prevalence (%)	0.12	0.12	0.11
Mean age at first event (years)	12.97	12.29	13.98

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.47 [1.34, 9.02]	1.1e-2	10
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: Q17_CLEFT_LIP_CLEFT_PALATE – Cleft lip, lip and palate or palate
GWS hits: 1

Survival analyses between endpoints

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Plot

before Cleft lip, lip and palate or palate
after Cleft lip, lip and palate or palate

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Cleft lip, lip and palate or palate

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