Cleft lip

Q17_CLEFT_LIP

cleft lip: ['Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 Q36

Hospital discharge: ICD-9 7491[A-G]

Hospital discharge: ICD-8 74910|7491[123]

Cause of death: ICD-10 Q36

Cause of death: ICD-9 7491[A-G]

Cause of death: ICD-8 74910|7491[123]

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

Q17_CLEFT_LIP

Extra metadata

First used in FinnGen datafreeze DF7

Similar endpoints

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List of similar endpoints to Cleft lip based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

Unadjusted prevalence (%)

0.02

Mean age at first event (years)

10.19

12.77

7.40

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: Q17_CLEFT_LIP – Cleft lip
GWS hits:

Survival analyses between endpoints

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Plot

before Cleft lip
after Cleft lip

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Cleft lip

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