Chronic kidney disease

N14_CHRONKIDNEYDIS

chronic kidney disease: Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 N18

Hospital discharge: ICD-9 585

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 N18

Cause of death: ICD-9 585

Cause of death: ICD-8 $!$

KELA reimbursements: KELA codes 138

6807

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6798

Check minimum number of events None

6798

Include endpoints

N14_DIALYSIS

6833

N14_CHRONKIDNEYDIS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 N17-N19

Name in latin Insufficientia renalis chronica

Similar endpoints

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List of similar endpoints to Chronic kidney disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Dialysis

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	6604	2232	4372
Unadjusted prevalence (%)	2.14	1.29	3.24
Mean age at first event (years)	65.81	63.92	66.77

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.11	8.96 [7.18, 11.18]	3.9e-84	1836
15 years	0.01	1.96 [1.54, 2.48]	3.0e-8	344
5 years	0.01	7.25 [6.09, 8.62]	<1e-100	692
1 year	0.01	28.81 [24.64, 33.70]	<1e-100	772

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: N14_CHRONKIDNEYDIS – Chronic kidney disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Chronic kidney disease
after Chronic kidney disease

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Table

Loading survival analyses table

Drugs most likely to be purchased after Chronic kidney disease

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