Lethal midline granuloma

M13_MIDGRANULOMA

lethal midline granuloma: An aggressive, progressive, and destructive lesion affecting the nasal cavities, paranasal sinuses, and the palate. The vast majority of cases are malignant lymphoproliferations affecting the midline of the face in patients with nasal type extranodal NK/T-cell lymphoma.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M31.2

Hospital discharge: ICD-9 4463

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M31.2

Cause of death: ICD-9 4463

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

M13_MIDGRANULOMA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M31

Name in latin Granuloma lineae medialis letalis

Similar endpoints

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List of similar endpoints to Lethal midline granuloma based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	14	7	7
Unadjusted prevalence (%)	0.00	0.00	0.01
Mean age at first event (years)	50.80	50.74	50.85

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_MIDGRANULOMA – Lethal midline granuloma
GWS hits:

Survival analyses between endpoints

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Plot

before Lethal midline granuloma
after Lethal midline granuloma

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Table

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Drugs most likely to be purchased after Lethal midline granuloma

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