Allergic urticaria

L12_URTICA_ALLERG

allergic urticaria: commonly referred to as hives, is a kind of skin rash notable for pale red, raised, itchy bumps. Hives may cause a burning or stinging sensation. Histamine and other proinflammatory substances are released from mast cells in the skin and tissues in response to the binding of allergen-bound IgE antibodies to high-affinity cell surface receptors. Basophils and other inflammatory cells are also seen to release histamine and other mediators, and are thought to play an important role, especially in chronic urticarial diseases.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 L50.0

Hospital discharge: ICD-9 7080

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 L50.0

Cause of death: ICD-9 7080

Cause of death: ICD-8 $!$

1947

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1868

Check minimum number of events None

1868

Include endpoints None

1868

L12_URTICA_ALLERG

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 L50

Name in latin Urticaria allergica

Similar endpoints

↥

List of similar endpoints to Allergic urticaria based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	1792	1257	535
Unadjusted prevalence (%)	0.58	0.72	0.40
Mean age at first event (years)	41.88	41.38	43.06

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.22 [2.17, 4.77]	6.5e-9	95
15 years	0.01	1.89 [1.29, 2.77]	1.0e-3	41
5 years	0.00	3.49 [2.21, 5.51]	7.5e-8	25
1 year	0.00	7.17 [3.64, 14.12]	1.2e-8	10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: L12_URTICA_ALLERG – Allergic urticaria
GWS hits: 0

Survival analyses between endpoints

↥

Plot

before Allergic urticaria
after Allergic urticaria

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Allergic urticaria

↥