Speech and linguistic disorders

KRA_PSY_SPEELING

autism: A disorder characterized by marked impairments in social interaction and communication accompanied by a pattern of repetitive, stereotyped behaviors and activities. Developmental delays in social interaction and language surface prior to age 3 years.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F80, F81

Hospital discharge: ICD-9 315[0-3]|3159

Hospital discharge: ICD-8 31610

Cause of death: ICD-10 F80, F81

Cause of death: ICD-9 315[0-3]|3159

Cause of death: ICD-8 31610

2143

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2091

Check minimum number of events None

2091

Include endpoints None

2091

KRA_PSY_SPEELING

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Speech and linguistic disorders based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1957	945	1012
Unadjusted prevalence (%)	0.63	0.54	0.75
Mean age at first event (years)	19.52	22.14	17.08

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.37 [1.39, 13.75]	1.2e-2	40
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: KRA_PSY_SPEELING – Speech and linguistic disorders
GWS hits: 0

Survival analyses between endpoints

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Plot

before Speech and linguistic disorders
after Speech and linguistic disorders

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Table

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Drugs most likely to be purchased after Speech and linguistic disorders

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