Irritable bowel syndrome

K11_IBS

irritable bowel syndrome: Gastrointestinal symptoms characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K58

Hospital discharge: ICD-9 5641

Hospital discharge: ICD-8 56419

Cause of death: ICD-10 K58

Cause of death: ICD-9 5641

Cause of death: ICD-8 56419

7436

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7294

Check minimum number of events None

7294

Include endpoints None

7294

K11_IBS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K55-K63

Name in latin Syndroma intestini irritabilis

Similar endpoints

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List of similar endpoints to Irritable bowel syndrome based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	7053	5155	1898
Unadjusted prevalence (%)	2.29	2.97	1.41
Mean age at first event (years)	48.93	48.35	50.50

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.50 [1.12, 2.01]	6.8e-3	362
15 years	0.01	0.99 [0.75, 1.31]	9.5e-1	178
5 years	0.00	1.48 [1.10, 1.99]	8.9e-3	80
1 year	0.00	3.12 [2.07, 4.68]	4.4e-8	31

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_IBS – Irritable bowel syndrome
GWS hits: 1

Survival analyses between endpoints

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Plot

before Irritable bowel syndrome
after Irritable bowel syndrome

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Table

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Drugs most likely to be purchased after Irritable bowel syndrome

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