Fissure and fistula of anal and rectal regions

K11_FISSANAL

anus disease: A non-neoplastic or neoplastic disorder that affects the anal canal or anal margin. Representative examples of non-neoplastic disorders include hemorrhoids and anal ulcer. Representative examples of neoplastic disorders include carcinoma, lymphoma, and melanoma. [database_cross_reference: NCIT:C26695]

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K60

Hospital discharge: ICD-9 565

Hospital discharge: ICD-8 565

Cause of death: ICD-10 K60

Cause of death: ICD-9 565

Cause of death: ICD-8 565

6850

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6850

Check minimum number of events None

6850

Include endpoints None

6850

K11_FISSANAL

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K55-K63

Name in latin Fissura/fistula regionis analis/rectalis

Similar endpoints

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List of similar endpoints to Fissure and fistula of anal and rectal regions based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	6610	3396	3214
Unadjusted prevalence (%)	2.14	1.96	2.38
Mean age at first event (years)	44.43	43.16	45.76

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.91 [0.69, 1.20]	5.2e-1	506
15 years	0.00	0.70 [0.54, 0.90]	6.1e-3	235
5 years	0.00	1.05 [0.79, 1.39]	7.3e-1	80
1 year	0.00	1.87 [1.21, 2.89]	4.7e-3	26

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_FISSANAL – Fissure and fistula of anal and rectal regions
GWS hits: 1

Survival analyses between endpoints

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Plot

before Fissure and fistula of anal and rectal regions
after Fissure and fistula of anal and rectal regions

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Table

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Drugs most likely to be purchased after Fissure and fistula of anal and rectal regions

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