Diaphragmatic hernia

K11_DIAHER

congenital diaphragmatic hernia: Congenital diaphragmatic hernia (CDH) is a posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K44

Hospital discharge: ICD-9 5513|5523|5533

Hospital discharge: ICD-8 5513

Cause of death: ICD-10 K44

Cause of death: ICD-9 5513|5523|5533

Cause of death: ICD-8 5513

9135

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

9135

Check minimum number of events None

9135

Include endpoints None

9135

K11_DIAHER

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K40-K46

Name in latin Hernia diaphragmatica

Similar endpoints

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List of similar endpoints to Diaphragmatic hernia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	8836	5260	3576
Unadjusted prevalence (%)	2.86	3.03	2.65
Mean age at first event (years)	59.92	59.56	60.46

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.07 [1.62, 2.66]	8.8e-9	867
15 years	0.01	1.15 [0.92, 1.42]	2.2e-1	384
5 years	0.00	2.58 [2.13, 3.11]	9.9e-23	292
1 year	0.00	5.04 [3.96, 6.41]	1.4e-39	113

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_DIAHER – Diaphragmatic hernia
GWS hits: 6

Survival analyses between endpoints

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Plot

before Diaphragmatic hernia
after Diaphragmatic hernia

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Table

Loading survival analyses table

Drugs most likely to be purchased after Diaphragmatic hernia

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