Coeliac disease

K11_COELIAC

celiac disease: An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K90.0

Hospital discharge: ICD-9 5790A

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K90.0

Cause of death: ICD-9 5790A

Cause of death: ICD-8 $!$

3022

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3022

Check minimum number of events None

3022

Include endpoints None

3022

K11_COELIAC

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K90

Name in latin Coeliacia

Similar endpoints

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List of similar endpoints to Coeliac disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2953	1975	978
Unadjusted prevalence (%)	0.96	1.14	0.72
Mean age at first event (years)	46.36	44.35	50.43

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.95 [1.28, 2.96]	1.8e-3	172
15 years	0.01	1.34 [0.90, 1.98]	1.5e-1	86
5 years	0.00	2.26 [1.48, 3.45]	1.5e-4	43
1 year	0.00	6.39 [3.77, 10.83]	5.3e-12	23

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_COELIAC – Coeliac disease
GWS hits: 16

Survival analyses between endpoints

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Plot

before Coeliac disease
after Coeliac disease

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Table

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Drugs most likely to be purchased after Coeliac disease

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