Interstitial lung disease

ILD

interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 J84

Hospital discharge: ICD-9 515|516

Hospital discharge: ICD-8 48499|51701

Cause of death: ICD-10 J84

Cause of death: ICD-9 515|516

Cause of death: ICD-8 48499|51701

3286

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3195

Check minimum number of events None

3195

Include endpoints None

3195

ILD

Extra metadata

First used in FinnGen datafreeze DF6

Parent code in ICD-10 J80-J84

Name in latin Alii morbi interstitiales pulmonum

Similar endpoints

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List of similar endpoints to Interstitial lung disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	3091	1245	1846
Unadjusted prevalence (%)	1.00	0.72	1.37
Mean age at first event (years)	65.34	62.89	67.00

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.53 [2.95, 6.95]	5.1e-12	758
15 years	0.01	1.59 [1.11, 2.27]	1.1e-2	202
5 years	0.01	5.22 [4.09, 6.66]	2.7e-40	282
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ILD – Interstitial lung disease
GWS hits: 8

Survival analyses between endpoints

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Plot

before Interstitial lung disease
after Interstitial lung disease

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Table

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Drugs most likely to be purchased after Interstitial lung disease

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