Atrial fibrillation and flutter


atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 I48
Hospital discharge: ICD-9 4273
Hospital discharge: ICD-8 42792
Cause of death: ICD-10 I48
Cause of death: ICD-9 4273
Cause of death: ICD-8 42792
KELA reimbursements: KELA codes 207|351
KELA reimbursements: ICD-10 I48


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Fibrillatio atriorum

Summary Statistics

Key figures

All Female Male
Number of individuals 34748 13256 21492
Unadjusted prevalence (%) 11.26 7.64 15.92
Mean age at first event (years) 67.31 69.39 66.02


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.98 [2.67, 3.33] 5.5e-83 7723
15 years 0.01 1.55 [1.39, 1.72] 1.9e-15 2907
5 years 0.00 3.40 [3.12, 3.71] <1e-100 2647
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_AF – Atrial fibrillation and flutter
GWS hits: 54

Survival analyses between endpoints


before Atrial fibrillation and flutter
after Atrial fibrillation and flutter

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Drugs most likely to be purchased after Atrial fibrillation and flutter