Atrial fibrillation and flutter

I9_AF

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I48

Hospital discharge: ICD-9 4273

Hospital discharge: ICD-8 42792

Cause of death: ICD-10 I48

Cause of death: ICD-9 4273

Cause of death: ICD-8 42792

KELA reimbursements: KELA codes 207|351

KELA reimbursements: ICD-10 I48

36412

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

35791

Check minimum number of events None

35791

Include endpoints

I9_E_DRONE

35791

I9_AF

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 I30-I52

Name in latin Fibrillatio atriorum

Similar endpoints

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List of similar endpoints to Atrial fibrillation and flutter based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	34748	13256	21492
Unadjusted prevalence (%)	11.26	7.64	15.92
Mean age at first event (years)	67.31	69.39	66.02

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.98 [2.67, 3.33]	5.5e-83	7723
15 years	0.01	1.55 [1.39, 1.72]	1.9e-15	2907
5 years	0.00	3.40 [3.12, 3.71]	<1e-100	2647
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_AF – Atrial fibrillation and flutter
GWS hits: 54

Survival analyses between endpoints

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Plot

before Atrial fibrillation and flutter
after Atrial fibrillation and flutter

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Table

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Drugs most likely to be purchased after Atrial fibrillation and flutter

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