Sensorineural hearing loss

H8_HL_SEN_NAS

sensorineural hearing loss: Hearing loss in which the root cause lies in the inner ear or sensory organ (cochlea and associated structures) or the vestibulocochlear nerve (cranial nerve VIII).

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H90.3, H90.4, H90.5

Hospital discharge: ICD-9 3891

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H90.3, H90.4, H90.5

Cause of death: ICD-9 3891

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

25233

H8_HL_SEN_NAS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

↥

List of similar endpoints to Sensorineural hearing loss based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	24479	11641	12838
Unadjusted prevalence (%)	7.93	6.71	9.51
Mean age at first event (years)	63.89	62.14	65.49

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.45 [1.25, 1.68]	6.1e-7	2835
15 years	0.01	0.89 [0.78, 1.02]	8.4e-2	1408
5 years	0.00	1.74 [1.55, 1.94]	2.5e-22	978
1 year	0.00	2.16 [1.82, 2.56]	4.1e-19	238

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: H8_HL_SEN_NAS – Sensorineural hearing loss
GWS hits: 12

Survival analyses between endpoints

↥

Plot

before Sensorineural hearing loss
after Sensorineural hearing loss

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Sensorineural hearing loss

↥